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Albumin-based therapeutics for potent immune stimulation

PhD defence, Friday 2 February 2024, Diego Pilati

Diego Pilati

During his PhD studies, Diego Pilati researched the potential of albumin as a scaffold for the delivery of immunotherapeutics. Albumin is the most abundant protein in human serum and can accumulate in tumours and lymph nodes, making it an ideal carrier for the design of immunotherapeutics. Diego Pilati studied how albumin could be functionalized with CpG ODN, an innate immunity stimulant, and PD-L1, a checkpoint inhibitor.

The new research findings contribute to the understanding of how to design efficient immunotherapeutics that restore the host immune system ability to recognize and eliminate tumour cells.

The PhD study was completed at Interdisciplinary Nanoscience Center (iNANO), Faculty of Natural Sciences, Aarhus University.

This summary was prepared by the PhD student.

Time: Friday, 2 February 2024 at 13:15
Place: Building 1593, room 012, Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Gustav Wieds Vej 14, 8000 Aarhus C
Title of PhD thesis: Exploiting FcRn-mediated Endosomal Accumulation using Albumin-CpG Oligonucleotide Conjugates for Potent Innate Immune System Stimulation in Cancer Therapy

Contact information: Diego Pilati, e-mail: pilati.diego92@gmail.com, tel.: +45 93933765

Members of the assessment committee:
Professor Peter Kristensen, Department of Chemistry and Bioscience, Aalborg University, Denmark

Professor Moein Moghimi, School of Pharmacy, Newcastle University, United Kingdom

Professor Mingdong Dong (chair), Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Denmark Denmark

Main supervisor:
Associate Professor Ken Howard, Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Denmark

Language: The PhD dissertation will be defended in English

The defence is public.
The PhD thesis is available for reading at the Graduate School of Natural Sciences/GSNS, Jens Baggesens Vej 53, building 5221, 8200 Aarhus N.

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