Aarhus University Seal

Catching and Combining Isotope Labeled Synthons via Hydroformylation

PhD defence, Thursday 1st February 2024, Hans Christian Dahl Hammershøj

Hans Christian Dahl Hammershøj

During his PhD studies, Hans Christian Dahl Hammershøj researched the scope and application potential of enacting hydro- and deuterioformylation as reactions for installing isotope labels in bioactive compounds. Hans Christian Dahl Hammershøj studied how in situ generated labeled synthons such as 13CO, 2H2, and carbon-13 labeled ethylene can be employed for multi- and site-selective labeling of organic molecules.

The new research findings expand the repertoire of labeling methods available for accessing labeled pharmaceuticals; substrates that are essential when elucidating the pharmacokinetic profile of drug candidates.

The PhD study was completed at the interdisciplinary Nanoscience Center, Faculty of Natural Sciences, Aarhus University.

This summary was prepared by the PhD student.

Time: Thursday, 1st February 2024 at 13.15
Place: Building 1427, room 246, Lecture Theatre M2, Studenterhuset, Aarhus University, Nordre Ringgade 3, 8000 Aarhus.
Title of PhD thesis: Development of Isotope Labeling Methods Enabled by Hydro- and Deuterioformylations of in situ Generated Labeled Gas Synthons
Contact information: Hans Christian Dahl Hammershøj, e-mail: hcdh@inano.au.dk, tel.: +4520850380

Members of the assessment committee:
Professor Clément Mazet, Department of Organic Chemistry, University of Geneva, Switzerland

Professor Robert Madsen, Department of Chemistry, Technical University of Denmark,Denmark

Professor Jan Skov Pedersen (chair), Interdisciplinary Nanoscience Center (iNANO),Aarhus University

Main supervisor:
Professor Troels Skrydstrup, Department of Chemistry, Aarhus University, Denmark

Language: The PhD dissertation will be defended in English

The defence is public.
The PhD thesis is available for reading at the Graduate School of Natural Sciences/GSNS,

Jens Baggesens Vej 53, building 5221, 8200 Aarhus N.

16882 / i43