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Creating a new synthetic biology tool with designer RNA-protein scaffolds

PhD defence, Thursday 22 April 2021, Michael Truong-Giang Anh Nguyen.

2021.04.29 | Mie Meulengracht Christensen

Michael Truong-Giang Anh Nguyen

During his PhD studies, Michael Truong-Giang Anh Nguyen developed tools for genetic encoding and expression of synthetic RNA-protein nanoscaffolds in Escherichia coli. RNA scaffolds can be applied for spatial control of proteins and monitoring of metabolites in cells for industrial bioproduction. Michael Truong-Giang Anh Nguyen designed RNA-protein scaffolds using an origami folding method for nanoscale design and investigated strategies for co-expression of RNA and proteins in bacterial cells.

The developments presented in this research set the foundation for the synthetic biology applications of RNA-protein nanoscaffolds in Escherichia coli.

The PhD study was completed at Interdisciplinary Nanoscience Center (INANO), Faculty of Natural Sciences, Aarhus University.

This summary was prepared by the PhD student.

Time: Thursday, April 29 2021 at 16:15
Place: The PhD defence will be held online.
To receive a link to the event, please send an e-mail to Ebbe Sloth Andersen, esa@inano.au.dk
Title of PhD thesis: Engineering RNA-Protein Nanoscaffolds for Synthetic Biology
Contact information: Michael Truong-Giang Nguyen, e-mail: mtan@inano.au.dk, tel.: +45 28211918
Members of the assessment committee:
Associate Professor Elisa Franco, Molecular Biology Institute, University of California, Los Angeles, USA
Associate Professor Jeppe Vinther, Department of Biology, University of Copenhagen, Denmark
Professor Jørgen Kjems (chairman), iNANO and Department of Molecular Biology and Genetics, Aarhus University, Denmark
Main supervisor:
Associate Professor Ebbe Sloth Andersen, iNANO and Department of Molecular Biology and Genetics, Aarhus University, Denmark
Language: The PhD dissertation will be defended in English

The defence is public.

Due to the coronavirus situation, the PhD thesis will not be available for reading at the offices of the PhD administration. Instead, interested parties may send an e-mail to gradschool.nat@au.dk to receive a digital copy of the PhD thesis. Please note, it may in certain cases be necessary to make an individual arrangement to read the PhD thesis.

PhD defence
16882 / i43