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Creation of artificial liver cell mimics, able to integrate and support natural liver cells

PhD defence, Tuesday 4 October 2022. Järvi Mika Spanjers.

Järvi Mika Spanjers

Creation of cell mimics was done by using hydrogel as a soft material to form the core of the cell mimic, to match the soft liver tissue. The connection of liver cells to the core was improved by the use of a coating made from cell membranes collected from liver cells. In order for the cell mimics to have function, a capsule made from lipids and polymers with an artificial enzyme were added to the cell mimics. Function was seen by the formation of product from a substrate by the cell mimics.
The cell mimics ability to connect with natural liver cell and supply product to the surrounding liver cells, makes them interesting in the potential treatment of liver failure.
The PhD study was completed at iNANO, Faculty of Natural Sciences, Aarhus University.

This summary was prepared by the PhD student.

Time: Tuesday, 4 October 2022 at 13:00
Place: Building 1510, room 213, Lecture Theatre VI, Department of Chemistry, Aarhus University, Langelandsgade 140, 8000 Aarhus C
Title of PhD thesis: Development of cell mimics for the support of hepatocytes

Contact information: J.M. Spanjers, e-mail: jmspanjers@inano.au.dk

Members of the assessment committee:

Professor, E. Thormann Department of chemistry, DTU, Denmark

Senior researcher F. Boulmedais, Institute for Advanced Study, Université de Strasbourg, France

Associate Professor, E. Ferapontova (chair), iNANO, Aarhus University, Denmark

Main supervisor:
Associate Professor, B.M. Städler, iNANO, Aarhus University, Denmark

Language: The PhD dissertation will be defended in English

The defence is public.
The PhD thesis is available for reading at the Graduate School of Natural Sciences/GSNS,

Jens Baggesens Vej 53, building 5221, 8200 Aarhus N.

16882 / i43