Aarhus University Seal / Aarhus Universitets segl

Inferring cellular microstructure from water diffusion – towards magnetic resonance imaging as a virtual microscope

PhD defence, Wednesday 29 June 2022, Jonas Lynge Olesen.

Jonas Lynge Olesen

Diffusion weighted magnetic resonance imaging (dMRI) holds the unique potential of non-invasively providing a window to the cellular microstructure and thereby improve the diagnoses and understanding of neurodegenerative diseases. This PhD study represents one more step towards realizing this potential. In particular, Jonas L. Olesen studied the functional behavior of the dMRI signal in experimental regimes made feasible by high field pre-clinical scanners. Thereby, it is made possible to disentangle the signal contributions from multiple microstructural sources providing insight, for instance, into the diffusion properties of neurites. The results further the understanding of microstructural modeling of the dMRI signal from neural tissue, especially in gray matter, which constitutes a new frontier in the field.

The PhD study was completed at the Department of Physics and Astronomy, Faculty of Natural Sciences, Aarhus University.

This summary was prepared by the PhD student.

Time: Wednesday, 29 June 2022, 14:00
Place: Building 1523, room 318, Lecture Theatre Fysisk Auditorium, Department of Physics and Astronomy, Aarhus University, Ny Munkegade 120, 8000 Aarhus C
Title of PhD thesis: Diffusion as a probe of structure: NMR virtual microscopy

Contact information: Jonas L. Olesen, e-mail: jonas@phys.au.dk, tel.: +45 42659765

Members of the assessment committee:

Associate professor Markus Nilsson, Diagnostic Radiology, Clinical Sciences, Lund University, Sweden

Assistant professor Ileana Jelescu, Department of Radiology, Lausanne University Hospital and University of Lausanne, Switzerland

Associate Professor Jan Arlt (chair), Department of Physics and Astronomy, Aarhus University, Denmark

Main supervisor:
Professor Sune Jespersen, Department of Clinical Medicine and Department of Physics and Astronomy, Aarhus University, Denmark

Language: The PhD dissertation will be defended in English

The defence is public.
The PhD thesis is available for reading at the Graduate School of Natural Sciences/GSNS,

Jens Baggesens Vej 53, building 5221, second floor, 8200 Aarhus N.

16882 / i43