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Modifying DNA for different applications, expanding on bioconjugation and light-responsive devices

PhD defence, Monday 2 May 2022, Angel Eduardo Santorelli Villamizar

Angel Eduardo Santorelli Villamizar

During his studies, Angel Santorelli researched new methods to functionalize oligonucleotides during the process of solid phase synthesis. Twelve different probes for different applications were tested, from bioconjugation to fluorophores and light-responsive systems. In addition, the development of photo-responsive systems involving azobenzene moieties and DNA are explored.

The new research findings expand on the current methods to produce customized oligonucleotides, with special groups as chemical handles and dyes, which are essential in modern life-science applications.

The PhD degree was completed at the Interdisciplinary Nanoscience Center (iNANO), Faculty of Natural Sciences, Aarhus University.

This summary was prepared by the PhD student.

Time: Monday 2 May 2022 at 13.15
Place: Building 1593, room 012,  iNANO auditorium, Interdisciplinary Nanoscience Center, Gustav Wieds Vej 14,  Aarhus University, 800 Aarhus C.
Title of dissertation: Chemical Manipulation of DNA: Photo-responsive Systems and The Expansion of Oligonucleotide Functionalization Toolkits
Contact information: Angel Eduardo Santorelli Villamizar, e-mail: angel.e.santorelli@inano.au.dk, tel.: +45 50288144
Members of the assessment committee:
Professor, Dr. Andriy Mokhir, Department of Chemistry and Pharmacy, Friedrich Alexander University Erlangen-Nürnberg, Germany
Associate Professor Stefan Vogel, Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Denmark
Professor Niels Christian Nielsen, iNANO and Department of Chemistry, Aarhus University (chair)
Main supervisor:
Professor Kurt Gothelf, iNANO and Department of Chemistry, Aarhus University
Language: The PhD dissertation will be defended in English

The defence is public.

The PhD thesis is available for reading at the Graduate School of Natural Sciences/GSNS, Katrinebjergvej 89F, building 5132, 8200 Aarhus N.

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