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Natural and Chemical Artificial Receptors in Disease Treatment

PhD defence, Tuesday 6 February 2024, Rikke Fabech Hansson

Rikke Fabech Hansson

During her PhD studies, Rikke Fabech Hansson researched natural and artificial receptors as drug targets. Receptors are the reason you can see, taste, and feel – part of an intricate network of signals in your entire body. They are, however, also involved in many disease mechanisms, and it is therefore desired to be able to control their activity. Rikke Fabech Hansson studied how to develop selective drugs with prolonged half-life based on peptides that can be used to control the activity of a specific receptor. Furthermore, chemical artificial internalising receptors were synthesised and used for a study of the relationship between the chemical structure and activity in vitro. 
The new research findings contribute to the development of new conjugation designs to increase half-life of peptide drugs in addition to new insights into the activity of chemical artificial internalising receptors for selective drug delivery through bioorthogonal recognition in vitro. 

The PhD study was completed at Department of Chemistry, Faculty of Natural Sciences, Aarhus University.
This summary was prepared by the PhD student.

Time: Tuesday, 6th of February 2024 at 9.00. 
Place: Building 1531, room 113 Lecture Theatre D1, Department of Mathematics, Aarhus University, Ny Munkegade 118, 8000, Aarhus C. 
Title of PhD thesis: Natural and Chemical Artificial Receptors - In Disease, Treatment and Drug Delivery
Contact information: Rikke Fabech Hansson, e-mail: rfh@chem.au.dk, tel.: +45 42925098

Members of the assessment committee:
Professor Seraphine V. Wegner, Institute of Physiological Chemistry and Pathobiochemistry, University of Münster, Germany

Professor  Simon J. Webb, School of Chemistry, University of Manchester, England

Associate Professor Marianne Glasius (chair), Department of Chemistry, Aarhus University, Denmark

Main supervisor:
Professor Alexander N. Zelikin, Department of Chemistry, Aarhus University, Denmark

Language: The PhD dissertation will be defended in English

The defence is public.

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