During her PhD studies, Stephanie J. Ton worked on the development of new transition metal-catalyzed reactions that have applications in the carbon isotope labeling of pharmaceuticals. The synthesis of isotopically labeled pharmaceuticals is essential for the advancement of pharmaceuticals from pre-clinical trials through phase three of drug development programs. However, due to the incredibly high cost associated with the radiolabeling reagents and handling of radioisotopes, new efficient methods for incorporating isotopes are highly valuable.

The new research findings outline three methods developed for efficient isotope labeling of various functional groups and provide mechanistic understanding to aid in future reaction design.

The PhD degree was completed at the Interdisciplinary Nanoscience Center (iNANO), Faculty of Natural Sciences, Aarhus University.

This summary was prepared by the PhD student.

Time: Thursday, 31 August 2023 at 13:15
Place: Building 1427, room 246, Auditorium M2, Conference Centre, Aarhus University, Fredrik Nielsens Vej 4, 8000 Aarhus C
Title of dissertation: Mechanistic Investigations into Nickel- and Palladium-Mediated Reactions and Their Applications in Isotope Labeling
Contact information: Stephanie J. Ton, e-mail: ston@inano.au.dk, tel.: +45 29605968
 

Members of the assessment committee:
Professor Davide Audisio, CEA - Commissariat à l'énergie atomique et aux énergies alternatives, France
Professor Robert Madsen, Department of Chemistry, Technical University of Denmark, Denmark
Professor Elena Ferapontov (chair), Interdisciplinary Nanoscience Center, Aarhus University, Denmark
 

Main supervisor:
Professor Troels Skrydstrup, Interdisciplinary Nanoscience Center, Aarhus University
 

Language: The PhD dissertation will be defended in English