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Polyvalency and the Blood Brain Barrier – Investigating multimerized peptides for brain delivery

PhD defence, Thursday 17 November 2022, Colin Ryan Mothershead.

Colin Ryan Mothershead

During his PhD studies, Colin Mothershead investigated how the multimerization of functional peptides influenced their interaction with brain capillary endothelial cells. Delivery of biopharmaceuticals across the blood brain barrier (BBB) to active sites in the central nervous system (CNS) remains one of the grand challenges in modern medicine. The BBB strictly controls the passage of molecules into the brain, restricting delivery of many promising biopharmaceuticals to 1-2% translocation efficiency. Utilizing a small self-assembling nucleic acid nanoscaffold, Colin Mothershead studied how combinations of peptides (homo- and heterogeneous) influenced the interaction of assemblies with cells comprising the BBB. Identifying distinct patterns and preferences of multivalent and combinatorial targeting capacity among the investigated peptides.
The new research findings contribute to the understanding of how multivalent and combinatorial targeting systems interact with the BBB and guide the design of drug delivery systems targeting the CNS.
The PhD study was completed at the Interdisciplinary Nanoscience Center, Faculty of Natural Sciences, Aarhus University and Novo Nordisk A/S, Måløv, Denmark.

This summary was prepared by the PhD student.

Time: Thursday 17 November 2022 at 13:15
Place: Online and Building1590, room 236, Aarhus University, Gustav Wieds Vej 14, 8000 Aarhus C
Title of PhD thesis: Multivalent and Multispecific Peptide Interactions at the Blood Brain Barrier

Contact information: Colin Mothershead, e-mail: colin.mothershead@gmail.com

Members of the assessment committee:

Professor Dan Peer, Department of Cell Research and Immunology, Tel-Aviv University, Israel

Professor Torben Moos, Department of Health Science and Technology, Aalborg University, Denmark

Associate Professor Ken Howard (chair), Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Denmark

Main supervisor:
Professor Jørgen Kjems, Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Denmark

Co-supervisors:
Dr. Jesper Lau, Research Chemistry, Novo Nordisk A/S, Måløv, Denmark

Dr. Stephen Buckley, Discovery ADME, Novo Nordisk A/S, Måløv, Denmark

Language: The PhD dissertation will be defended in English

The defence is public.
The PhD thesis is available for reading at the Graduate School of Natural Sciences/GSNS,

Jens Baggesens Vej 53, building 5221, 8200 Aarhus N.

16882 / i43