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Preparation and utilization of thioglycosides in oligosaccharide synthesis

PhD defence, Friday 25 November 2022. Helle Himmelstrup Trinderup.

Helle Himmelstrup Trinderup

Together with nucleic acids, lipids and proteins, carbohydrates constitute the four groups of biomolecules, which are essential for life on Earth. Carbohydrates constitute the most complex group due to complicated spacial structure of these. Furthermore, carbohydrates exist as simple building blocks or as longer chains called oligosaccharides. It is important to be able to connect the building blocks correctly to achieve the desired biological activity. During her PhD studies, Helle Trinderup has developed a “greener” method for preparing the building blocks and researched the glycosylation reaction, which is the reaction used to assemble the building blocks. However, the glycosylation reaction often results in complex mixtures of products, which complicates the preparation of oligosaccharides. Helle Trinderup has thoroughly studied the parameters, which affects the glycosylation reaction, and demonstrated that simple changes in the reaction conditions can change the selectivity. The obtained research results contribute to the understanding of the glycosylation reaction and potentially to the future preparation of oligosaccharides.

The PhD study was completed at Department of Chemistry, Faculty of Natural Sciences, Aarhus University.

This summary was prepared by the PhD student.

Time: Friday, november 25th 2022, at 13.00
Place: Building 1532, room 116, Lecture Theatre G1, Department of Mathematics, Aarhus University, Ny Munkegade 118, 8000 Aarhus C
Title of PhD thesis: Improving the Preparation and Utilization of Thioglycosides

Contact information: Helle Trinderup, e-mail: htrinderup@chem.au.dk, tel.: +45 30957377

Members of the assessment committee:
Associate Professor Thomas J. Boltje, Radboud University, Nijmegen, Netherlands

Associate Professor Christian Marcus Pedersen, Department of Chemistry, University of Copenhagen, Denmark

Professor Thomas Poulsen (chair), Department of Chemistry, Aarhus University, Denmark

Main supervisor:
Associate Professor Henrik Helligsø Jensen, Department of Chemistry, Aarhus University, Denmark

Language: The PhD dissertation will be defended in English

The defence is public.
The PhD thesis is available for reading at the Graduate School of Natural Sciences/GSNS,

Jens Baggesens Vej 53, building 5221, 8200 Aarhus N.

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