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Protein-lipid complexes in industrial and biological systems

PhD defence, Friday 27 January 2023. Helena Østergaard Rasmussen.

Helena Østergaard Rasmussen

During her PhD studies, Helena Østergaard Rasmussen investigated how industrial enzymes and amyloid proteins interact and form complexes with lipids. Amyloid proteins form large robust structures called fibrils. They are involved in Alzheimer’s and Parkinson’s disease where the formation of fibrils damages the brain cells. The fibril structure can also be utilized in a functional manner for forming a protective layer for bacteria or storing hormones in humans. Understanding protein-lipid complex formation is important for product development for example for laundry detergent formulations and for understanding the mechanisms of amyloid fibril formation.

The PhD study was completed at Interdisciplinary Nanoscience Center (iNANO), Faculty of Natural Sciences, Aarhus University and at Department of Life Sciences, Faculty of Natural Sciences, Imperial College London.

This summary was prepared by the PhD student.

Time: Friday, 27 January 2023 at 13.15
Place: Building 1593, room 012, Lecture Theatre iNANO AUD, iNANO, Aarhus University, Gustav Wieds Vej 14, 8000 Aarhus C
Title of PhD thesis: When Proteins meet Lipids: Investigating Complexes and the Effects on Activity and Fibrillation

Contact information: Helena Østergaard Rasmussen, e-mail: helena@inano.au.dk, tel.: +45 60600933

Members of the assessment committee:
Associate Professor Annette Eva Langkilde, Department of Drug Design and Pharmacology, University of Copenhagen, Denmark

Professor Tommy Nylander, Department of Chemistry, Lund University, Sweden

Associate Professor Victoria Birkedal (chair), iNANO and Department of Chemistry, Aarhus University, Denmark

Main supervisor:
Professor Jan Skov Pedersen, iNANO and Department of Chemistry, Aarhus University, Denmark

Professor Daniel Otzen, iNANO and Department of Molecular Biology and Genetics, Aarhus University, Denmark

Language: The PhD dissertation will be defended in English

The defence is public.
The PhD thesis is available for reading at the Graduate School of Natural Sciences/GSNS,

Jens Baggesens Vej 53, building 5221, 8200 Aarhus N.

16882 / i43