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Regulation of coagulation protease Factor X – gaining an understanding of the bleeding disorder Hemophilia

PhD defence, Wednesday, 25 May 2022, Amalie Carnbring Bonde.

Amalie Carnbring Bonde

During her PhD studies, Amalie Carnbring Bonde researched the proteins in the human blood coagulation system. Normal blood flow is maintained by pro- and anti-coagulant pathways and is vital to life, as blood transports nutrients and oxygen to the cells, and transports waste products away from the cells. Upon damage of the tissue, the coagulation system triggers a downstream cascade of coagulation protease activation steps which eventually leads to the formation of a blood clot to stop the bleeding. Amalie Carnbring Bonde studied how one of the proteins in the coagulation system, the coagulation protease called Factor X, is regulated to maintain normal blood flow.

 

The new research findings contribute to the understanding of how Factor X is regulated during coagulation, which potentially can improve treatment opportunities for patients with suffering from the genetic bleeding disorder Hemophilia.

The PhD study was completed in collaboration with Novo Nordisk A/S and Department of Molecular Biology and Genetics, Faculty of Natural Sciences, Aarhus University.

This summary was prepared by the PhD student.

Time: Wednesday, 25 May 2022 at 14:00
Place: Building 1872-447, room 4 (24), Department of Molecular Biology and Genetics, Aarhus University, Universitetsbyen 81, 8000 Aarhus C
Title of PhD thesis: Enzyme kinetics and structural characterization of Factor X regulation mechanisms
Contact information: Amalie Carnbring Bonde, e-mail: ma_ba5@hotmail.com, tel.: +45 60804717

Members of the assessment committee:

Professor Hans Brandstetter, Department of Molecular Biology, University of Salzburg, Austria

Professor Michael Overgaard, Department of Chemistry and Bioscience, Aalborg University, Denmark

Professor Ditlev Egeskov Brodersen (chairman), Department of Molecular Biology and Genetics, Aarhus University, Denmark

Main supervisor:
Professor Gregers Rom Andersen, Department of Molecular Biology and Genetics, Aarhus University, Denmark

Co-supervisor:
Principal scientist Jacob Lund, Novo Nordisk A/S, Denmark

Principal scientist Jais Rose Bjelke, Novo Nordisk A/S, Denmark

Principal scientist Eva Johansson, Novo Nordisk A/S, Denmark

Language: The PhD dissertation will be defended in English

The defence is public.
The PhD thesis is available for reading at the Graduate School of Natural Sciences/GSNS,

Katrinebjergvej 89F, building 5132, 8200 Aarhus N.

16882 / i43