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Small-scale hydroformylation of terminal alkenes for isotope labeling

PhD defence, Wednesday 22 June 2022. Samuel Kjærsgaard.

Samuel Kjærsgaard

During his PhD studies, Samuel Kjærsgaard developed a method for conducting small-scale hydroformylations in a two-chamber reactor. This newly developed methodology has eliminated the need for storing the dangerous gasses carbon monoxide and dihydrogen for small-scale hydroformylations. Instead of injecting the gasses directly from a pressurized gas cylinder into a reaction chamber, the gasses are liberated by stable gas releasing molecules in one chamber and diffuses into the second chamber of the two-chamber reactor, where the hydroformylation takes place. The usefulness of the methodology was illustrated by the synthesis and carbon-13 isotope labeling of the active pharmaceutical ingredient (API) for several blockbuster drugs. Furthermore, the methodology was adapted for the synthesis of [13C3]-propionaldehyde which was subsequently used to synthesize several [13C3]-API’s.


The PhD study was completed at Interdisciplinary Nanoscience Center (iNANO), Faculty of Natural Sciences, Aarhus University.

This summary was prepared by the PhD student.

Time: Wednesday, 22 June 222 at 13:15
Place: Building 1593 room 012, iNANO auditorium, iNANO, Aarhus University, Gustav Wieds Vej 14, 8000 Aarhus C
Title of PhD thesis: Small-Scale Hydroformylation Enabled by Multi-Chamber Reactors and Stable Gas Surrogates –For Incorporation of Carbon Isotopes
Contact information: Samuel Kjærsgaard, e-mail: skp@inano.au.dk, tel.: +45 28578904

Members of the assessment committee:

Dr. Davide Audisio, Frédéric Joliot Institute for Life Sciences, French Alternative Energies and Atomic Energy Commission (CEA), France

Professor Robert Madsen, Department of Chemistry, Technical University of Denmark, Denmark

Professor Alexander N. Zelikin, iNANO and Department of Chemistry, Aarhus University (Chair)

Main supervisor:
Professor Troels Skrydstrup, iNANO, Aarhus University, Denmark

Language: The PhD dissertation will be defended in English

The defense is public.
The PhD thesis is available for reading at the Graduate School of Natural Sciences/GSNS,

Jens Baggesens Vej 53, building 5221, second floor, 8200 Aarhus N.

16882 / i43