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Solving challenges with transition metals within isotopic labeling, lignin valorization, and bioconjugation

PhD defence, Friday 18 November 2022, Simon Steffen Pedersen

Simon Steffen Pedersen

During his PhD studies, Simon Steffen Pedersen investigated nickel-mediated carbonylative methods for the implementation of 13C- and 14C-isotopes into aliphatic ketones and carboxamides. Isotopic labeling is an important tool for pharmacokinetic studies during drug development. Simon Steffen Pedersen also studied a valorization strategy for the under-utilized bioresource lignin, which through catalytic transformations yielded a biobased monomer for polyester synthesis. Since polyesters, like polyethylene terephthalate, are currently synthesized from crude oil products, green synthetic routes, such as from lignin, are of high demand. Lastly, Simon Steffen Pedersen studied bioconjugation reactions of proteins and peptides with transition metal promoters. Methionine conjugation could be achieved by oxidation followed by cross-coupling, while separate work explored a copper-mediated arginine-selective modification with an ex situ mesyl chloride-triethylamine system.

The PhD study was completed at the Interdisciplinary Nanoscience Center (iNANO), Faculty of Natural Sciences, Aarhus University.

This summary was prepared by the PhD student.

Time: Friday, 18 November 2022 at 13:15
Place: Building 1523, room 318, Fysisk Auditorium, Department of Physics and Astronomy, Aarhus University, Ny Munkegade 120, 8000, Aarhus C
Title of PhD thesis: Transition Metal Promoted Reactions for Isotope Labeling, Lignin Valorization, and Bioconjugation

Contact information: Simon Steffen Pedersen, e-mail: ssp@inano.au.dk, tel.: +45 26145607

Members of the assessment committee:

Directeur de Recherche au CNRS Marc Taillefer, Centre National de la recherche scientifique (CNRS), École Nationale Superieure de Chimie de Montpellier (ENSCM), France

Associate Professor Jiwoong Lee, Department of Chemistry, University of Copenhagen, Denmark

Professor Niels Christian Nielsen (chair), Department of Chemistry, Aarhus University, Denmark

Main supervisor:
Professor Troels Skrydstrup, iNANO, Aarhus University, Denmark

Language: The PhD dissertation will be defended in English

The defence is public.
The PhD thesis is available for reading at the Graduate School of Natural Sciences/GSNS,

Katrinebjergvej 89F, building 5132, 8200 Aarhus N.

16882 / i43