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Synthesis of natural product inspired antibiotics

PhD defence, Friday 9 December 2022, Jaime Moyano Villameriel

Jaime Moyano Villameriel

During his PhD studies, Jaime Moyano Villameriel designed and implemented chemical syntheses to produce novel molecules that resemble natural products. Natural products are an important source for novel antibiotics, but their direct application for human use is often blocked by toxicity effects. Jaime Moyano Villameriel used synthetic chemistry to generate analogues of natural antibiotics. These novel molecules display activity against drug-resistant bacteria, and, at the same time, show reduced toxicity side-effects.

These new compounds will contribute to the development of efficient and safe human medicines in the future.

The PhD study was completed at the Department of Chemistry, Faculty of Natural Sciences, Aarhus University.

This summary was prepared by the PhD student.

Time: Friday, 9th December 2022 at 12.30
Place: Building 1514, room 213, Lecture Theatre Auditorium I, Department of Chemistry, Aarhus University, Langelandsgade 140, 8000 Aarhus C
Title of PhD thesis: Understanding the activity of carboxyl polyether ionophore lasalocid acid A

Contact information: Jaime Moyano Villameriel, e-mail: jaimemv@chem.au.dk, tel.: +45 91927148

Members of the assessment committee:

Associate Professor Michael Pittelkow, Department of Chemistry, University of Copenhagen, Denmark

Professor Daniel Strand, Department of Chemistry, Lund University, Sweden

Professor Henrik Stapelfeldt (chair), Department of Chemistry, Aarhus University, Denmark

Main supervisor:

Professor Thomas B. Poulsen, Department of Chemistry, Aarhus University, Denmark

Language: The PhD dissertation will be defended in English

The defence is public.
The PhD thesis is available for reading at the Graduate School of Natural Sciences/GSNS,

Jens Baggesens Vej 53, building 5221, 8200 Aarhus N.

16882 / i43