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The insulin receptor – how insulin binding causes insulin receptor signaling

PhD defence, tuesday, 27 September 2022. Jeppe Achton Nielsen.

Jeppe Achton Nielsen

During his/her PhD studies, Jeppe Achton Nielsen researched the three dimensional structure of the insulin receptor and investigated how insulin binds and create signaling via the receptor. Insulin receptor signaling is essential for the human body’s ability to regulate blood glucose, reduced insulin receptor signaling is a  hallmark of diabetes.


The new research findings contribute to the understanding of  how insulin activate the insulin receptor, and how the insulin receptor structure is coupled to insulin signaling.


The PhD study was completed at Department of Molecular Biology and Genetics, Faculty of Natural Sciences, Aarhus University and at Novo Nordisk A/S.

This summary was prepared by the PhD student.

Time: Tuesday, 27 September 2022 at 10:15
Place: Building 1870, room 816, Faculty club, Department of Molecular Biology and Genetics, Aarhus University, Universitetsbyen 81, 8000 Aarhus C
Title of PhD thesis: Structural studies of the human insulin receptor isoform A, hIR-A, using cryo-electron microscopy

Contact information: Jeppe Achton Nielsen, e-mail: jan@mbg.au.dk, tel.: +45 53570313

Members of the assessment committee:

Senior Lecturer Doryen A. Bubeck, Department of Life Sciences, Imperial College London, UK

Professor Michael T. Overgaard, Department of Chemistry and Bioscience, Aalborg University, Denmark

Associate Professor Anni H. Andersen (chair), Department of Molecular Biology and Genetics, Aarhus University, Denmark

Main supervisors:
Professor Poul Nissen, Department of Molecular Biology and Genetics, Aarhus University, Denmark

Principal Scientist Gerd Schluckebier, Novo Nordisk A/S, Denmark

Senior Researcher Thomas Boesen, Interdisciplinary Nanoscience Center, Aarhus University, Denmark

Principal Scientist Rita Slaaby, Novo Nordisk A/S, Denmark

Specialist Scientist Tina Hummelshøj, Novo Nordisk A/S, Denmark

Language: The PhD dissertation will be defended in English

The defence is public.
The PhD thesis is available for reading at the Graduate School of Natural Sciences/GSNS,

Jens Baggesens Vej 53, building 5221, 8200 Aarhus N.

16882 / i43