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Understanding how glyphosate is microbially degraded – Investigating the enzyme machinery for phosphonate degradation

PhD defence, Thursday 25 november 2021. Søren Kirk Amstrup

2021.11.25 | Frederikke Kongsted Hansen

Søren Kirk Amstrup

During his PhD studies Søren Kirk Amstrup has investigated microbial phosphonate degradation. This has given insight into how different microorganism are able to turnover a wide variety of highly stable phosphonate compounds. Most of these phosphonate compounds are rather stable in nature and demand highly specialized enzymes to drive their degradation. Søren investigated the carbon-phosphorus (C-P) lyase enzyme machinery and by cryogenic electron microscopy has discovered how it is able to utilize a wide range of substrates. This helps to explain how the C-P lyase machinery can be utilized for bioremediation of different phosphonate compounds, among which is the active compound in RoundUp®, glyphosate.

The PhD study was completed at the department of Molecular Biology and Genetics, Faculty of Natural Sciences, Aarhus University. This summary was prepared by the PhD student.

Time: Thusday, 25 November 2021 at 14:00.

Place: Building 1251, room 204, Lecture Theatre Eduard Biermann, Søauditorierne, Aarhus University, Bartholins Allé 3, 8000 Aarhus C and online. To receive a link to the event, please send an e-mail to Ph.D. Supervisor Ditlev Egeskov Brodersen (deb@mbg.au.dk) or chair Jan Trige Rasmussen (jatr@mbg.au.dk).

Title of PhD thesis: ABCs of phosphonate catabolism: ATPase driven dynamics of the carbon-phosphorus lyase core complex

Contact information: Søren Kirk Amstrup, e-mail: ska@mbg.au.dk, tel.: +45 26 35 00 11

Members of the assessment committee:
Professor David Zechel, Department of Chemistry, Queen's University, Kingston, Ontario, Canada
Professor Lutz Schmitt, Institute of Biochemistry, Heinrich Heine University Düsseldorf, Germany
Chair: Senior researcher Jan Trige Rasmussen, Department of Molecular Biology and Genetics, Aarhus University

Main supervisor: Professor Ditlev Egeskov Brodersen, Department of Melecular Biology and Genetics, Aarhus University, Denmark

Language: The PhD dissertation will be defended in English

The defence is public. The PhD thesis is available for reading at the Graduate School of Natural Sciences/GSNS, Katrinebjergvej 89F, building 5132, 8200 Aarhus N.

PhD defence
16882 / i43