Palladium oxidative addition complexes for radioisotope labeling

During his/her PhD studies, Daniel Vrønning Hoffmann researched new methods for carbon isotope labeling. The primary method studied was through palladium oxidative addition complexes, which carry the isotope-labeled carbon, originating from carbon monoxide. Daniel Vrønning Hoffmann studied how these complexes can be coupled with privileged motifs, resulting in high-yielding full incorporation of the desired carbon-14 isotope. Incorporation of both amides and esters was performed, as well as unnatural amino acids.

The new research findings contribute to the understanding of how more effective methods for carbon isotope labeling can be designed, which is an important step for the development of new drug molecules.

The PhD study was completed at the Interdisciplinary Nanoscience Center (iNANO), Faculty of Natural Sciences, Aarhus University.

This summary was prepared by the PhD student.

Time: Friday, 30th of October 2026 at 13:15
Place: Building 1593, room 012, iNANO AUD, iNANO, Aarhus University, Gustav Wieds Vej 14, 8000 Aarhus C
Title of PhD thesis: Development of Carbon Isotope Labeling Methods Employing CO to Target Esters and Amides 
Contact information: Daniel Vrønning Hoffmann, e-mail: dvh@chem.au.dk, tel.: +45 30129879
Members of the assessment committee:
Dr. and group director Davide Audisio, Frédéric Joliot Institute for Life Sciences, Commissariat à l'énergie atomique et aux énergies alternatives, France.
Professor Mikael Bols, Department of Chemistry, University of Copenhagen, Denmark.
Professor Duncan Sutherland (chair), Department of Chemistry, Aarhus University, Denmark.
Main supervisor: Professor Troels Skrydstup, Department of Chemistry, Aarhus University, Denmark
Language: The PhD dissertation will be defended in English

The defence is public.
The PhD thesis is available for reading at the Graduate School of Natural Sciences/GSNS, Ny Munkegade 120, building 1521, 8000 Aarhus C