During her PhD studies, Victoria aimed to investigate the C-terminal domains of the memory-related proteins SorCS1-3. These domains, which are intrinsically disordered in nature, have been chronically understudied due to their incompatibility with traditional structural biology techniques. Using a mixture of protein biochemistry, mammalian cell work, and bioimaging, Victoria mapped C-terminal interactomes of all three proteins, ultimately validating and characterising an activity-dependent interaction between SorCS3 and the synaptic scaffolding protein CASK in primary neurons.

The PhD study was completed at the Department of Molecular Biology and Genetics, Faculty of Natural Sciences, Aarhus University.

This summary was prepared by the PhD student.

Time: Wednesday 25^th March 2026, 13:00
Place: Building 1870, 120 (Nucleus), Department of Molecular Biology and Genetics, Aarhus University, Universitetsbyen 81, 8000 Aarhus C
Title of PhD thesis: Uncovering novel interactions of the SorCS1-3 C-terminal domains 
Contact information: Victoria Twiddy, e-mail: toriatwiddy tel.: +45 31692433
Members of the assessment committee:
Professor Jakob Balslev Sørensen, Department of Neuroscience, University of Copenhagen, Denmark
Group Leader Luis Filipe Ribeiro, Multidisciplinary Institute for Ageing, University of Coimbra, Portugal
Chair: Senior Researcher Jan Trige Rasmussen, Department of Molecular Biology and Genetics, Aarhus University 
Main supervisor: Associate Professor Magnus Kjærgaard, Department of Molecular Biology and Genetics, Aarhus University, Denmark
Co-supervisor: Associate Professor Lilian Kisiswa, Department of Molecular Biology and Genetics, Aarhus University, Denmark
Language: The PhD dissertation will be defended in English

The defence is public.
The PhD thesis is available for reading at the Graduate School of Natural Sciences/GSNS, Ny Munkegade 120, building 1521, 8000 Aarhus C