During her studies, Amanda investigated the molecular dynamics of the insulin receptor (IR), a key protein in regulating blood sugar levels. She explored how different insulin binding sites influence the receptor’s stability and activation, with a focus on a specific site that plays a critical role.

Her research revealed that when insulin binds to this particular site, it significantly stabilizes the receptor, which is essential for its proper function. These findings enhance our understanding of the insulin receptor’s operation and could lead to improved treatments for diabetes by targeting these crucial interactions.
The PhD study was completed at Department of Chemistry, Faculty of Natural Sciences, Aarhus University.

This summary was prepared by the PhD student.

Time: Tuesday, 19^th November at 14.15
Place: Building 1510-213 Aud. VI, Lecture Theatre, Department of Chemistry, Aarhus University, Langelandsgade 140, 8000 Aarhus
Title of PhD thesis: Under the Computational Microscope: Insights into the Insulin Receptor's Conformational Landscape
Contact information: Amanda Dyrholm Stange, e-mail: ads@chem.au.dk, tel.: +45 53809078
Members of the assessment committee:
Professor Syma Khalid, Department of Biochemistry, Oxford University, UK
Directeur Massimiliano Bonomi, Department of Structural Biology and Chemistry, Institut Pasteur, Paris, France
Associate Professor Tobias Weidner (chair), Department of Chemistry, Aarhus University, Denmark
Main supervisor:
Professor Birgit Schiøtt, Department of Chemistry, Aarhus University, Denmark
Co-supervisor:
Assistant Professor Nils Berglund, Department of Chemistry, Aarhus University, Denmark
Language: The PhD dissertation will be defended in English

The defence is public.
The PhD thesis is available for reading at the Graduate School of Natural Sciences/GSNS, Ny Munkegade 120, building 1521, 8000 Aarhus C