During her PhD studies, Simone Fjordside studied metabolite alterations in well-known preclinical models of type 2 diabetes using nuclear magnetic resonance (NMR) spectroscopy. Understanding the translational value and suitability of preclinical models is essential, as the preclinical phase of drug development relies on testing in different cell-based and animal models. Simone’s work seeks to explore the translational relevance of the frequently used preclinical models concerning metabolite alterations and the relevance of establishing an in-cell NMR for studying real-time metabolomics.

The PhD study was completed at Interdisciplinary Nanoscience Center (iNANO), Faculty of Natural Science, Aarhus University, Department of Diabetes Pharmacology, Novo Nordisk A/S and Department of Biophysics & Injectable Formulations, Novo Nordisk A/S.

This summary was prepared by the PhD student.

Time: Friday, 2^nd of May 2025 at 13:15
Place: Building 1593, room 012, Lecture Theatre iNANO Aud., iNANO, Aarhus University, Gustav Wieds Vej 14, 8000 Aarhus
Title of PhD thesis: Evaluation of type 2 diabetic models using NMR spectroscopy
Contact information: Simone Fjordside, e-mail: sf@inano.au.dk, tel.: +45 28 26 38 05
Members of the assessment committee:
Professor Nils Billestrup, Department of Biomedical Science, University of Copenhagen, Denmark
Professor Ulrich Günther, Institute of Chemistry and Metabolomics, University of Lübeck, Germany
Professor Niels Christian Nielsen (chair), Interdisciplinary Nanoscience Center, Aarhus University, Denmark
Main supervisor: Associate Professor Frans A. A. Mulder, Interdisciplinary Nanoscience Center, Aarhus University, Denmark
Co-supervisor: 
Dr. Maiken Højgaard Pedersen, Department of Diabetes Pharmacology, Novo Nordisk A/S, Denmark
Dr. Andrew J. Benie, Department of Biophysics and Injectable Formulations, Novo Nordisk A/S, Denmark
Language: The PhD dissertation will be defended in English

The defence is public.
The PhD thesis is available for reading at the Graduate School of Natural Sciences/GSNS, Jens Baggesens Vej 53, building 5221, 8200 Aarhus N.