Design and synthesis of interlocked nucleic acids for controlled protein homeostasis and antibacterial functions

Applications are invited for a PhD fellowship/scholarship at Graduate School of Natural Sciences, Aarhus University, Denmark, within the Molecular Biology and Genetics programme. The position is available from November 2026 or later. 

 

Title:
Design and synthesis of interlocked nucleic acids for controlled protein homeostasis and antibacterial functions

Research area and project description:
Are you passionate about novel oligonucleotide-based methods for controlling gene expression in synthetic biology and therapeutics? Are you interested in developing dynamic systems and molecular motors for precise protein regulation?

A 3-year PhD position is available for the development of biohybrid interlocked nucleic acids in the group of Assist. Professor Julián Valero, located at the interdisciplinary nanoscience center (iNANO) at Aarhus University. The position is available from October 2026 or shortly after.

The aim of the project is to develop a novel class of nucleic-acid based, biohybrid interlocked molecules (BIMs) for controlled protein homeostasis and novel antibacterial functions. This research involves a multifaceted approach, including: i) the design and synthesis of cyclic oligonucleotides and their assembly into nucleic acid-based interlocked motors and switches; ii) their application in controlled gene expression and protein homeostasis; iii) research on novel antibacterial pathways with promise against bacterial resistance; and iv) reversible control of cell function, further exploring their potential biomedical use.

This position is part of an EU funded ERC interdisciplinary, collaborative project at the interface between nucleic-acid chemistry, DNA/RNA nanotechnology and cell biology.

For technical reasons, you must upload a project description. When - as here - you apply for a specific project, please simply copy the project description above, and upload it as a PDF in the application. If you wish to, you can indicate an URL where further information can be found.

Qualifications and specific competences:
Applicants must have a relevant Master’s degree or in the process of getting a Master’s degree in nanoscience, chemistry, biochemistry, molecular biology, or related fields, preferably with a good track record.

• You should have hands-on experience in nucleic acid (DNA and RNA) experimental work.
• The ideal candidate should possess knowledge in organic chemistry and bioconjugation techniques, preferentially with experimental experience.
• Background on DNA and RNA nanotechnology and nucleic acid chemistry is a plus.
• Background on mammalian cell expression, cell culture and related assays is a plus.
• Background on bacterial growth, culture methods, and antibacterial agents is a plus.
• You are a team-player, collaborative and highly motivated to pursue scientific milestones of high standard.
• You are curious and self-driven, willing to learn new techniques. You should enjoy working on multidisciplinary projects and solving nanotechnology and synthetic biology challenges.
• Good communications skills in written and oral English, as this will be part of your daily work.
   

Place of employment and place of work:
The place of employment is Aarhus University, and the place of work is Department of Molecular Biology and Genetics, Gustav Wieds Vej 14, 8000 Aarhus C, Denmark (iNANO), Denmark. 

Contacts:
Applicants seeking further information for this project are invited to contact: 
Assistant Professor Julián Valero, jvalero@mbg.au.dk

How to apply:

For information about application requirements and mandatory attachments, please see the Application guide. Please read the Application guide thoroughly before applying.

When ready to apply, go to https://phd.nat.au.dk/for-applicants/apply-here/ (Note, the online application system opens 1 June 2026)

1. Choose August 2026 Call with deadline 1 August 2026 at 23:59 CEST.
2. You will be directed to the call and must choose the programme “Molecular Biology and Genetics”.
3. In the boxed named “Study”: In the dropdown menu, please choose: “Design and synthesis of interlocked nucleic acids for controlled protein homeostasis and antibacterial functions (Dsinac)”

Please note:

• The programme committee may request further information or invite the applicant to attend an interview.

At the Faculty of Natural Science at Aarhus University, we strive to support our scientific staff in their career development. We focus on competency development and career clarification and want to make your opportunities transparent. On our website, you can find information on all types of scientific positions, as well as the entry criteria we use when assessing candidates. You can also read more about how we can assist you in your career planning and development.

Aarhus University’s ambition is to be an attractive and inspiring workplace for all and to foster a culture in which each individual has opportunities to thrive, achieve and develop. We view equality and diversity as assets, and we welcome all applicants. All interested candidates are encouraged to apply, regardless of their personal background. Salary and terms of employment are in accordance with applicable collective agreement.