During her PhD studies, Ragnhild Laursen improved the analysis of mutational counts in cancer tumors. The aim of this analysis is to identify common mutational processes associated with specific cancer types or treatment groups, leading to a deeper understanding of cancer. Ensuring that these identified mutational processes are reliable and robust is essential. Ragnhild Laursen studied the analysis of mutational counts using known statistical principles to create a more adequate analysis of count data.

The new research has contributed with better analyses tools for count data in general, but in particular for the analysis of cancer genomics data.

The PhD study was completed at Department of Mathematics, Faculty of Natural Sciences, Aarhus University.

This summary was prepared by the PhD student.

Time: Friday, 22 November 2024 at 14.30
Place: Building 1531, room 119, Aud. D2, Department of Mathematics, Aarhus University, Ny Munkegade 118, 8000 Aarhus C
Title of PhD thesis: Non-negative matrix factorization for cancer genomics
Contact information: Ragnhild Laursen, e-mail: ragnhild@math.au.dk, tel.: +45 53280885
Members of the assessment committee:
Assistant Professor Eszter Lakatos, Department of Mathematical Sciences, Chalmers University of Technology, Sweden
Associate Professor Jes Frelsen, Department of Applied Mathematics and Computer Science, Danish Technical University, Denmark
Associate Professor Markus Kiderlen (chair), Department of Mathematics, Aarhus University, Denmark
Main supervisor:
Professor Asger Hobolth, Department of Mathematics, Aarhus University, Denmark
Language: The PhD dissertation will be defended in English

The defence is public.
The PhD thesis is available for reading at the Graduate School of Natural Sciences/GSNS, Ny Munkegade 120, building 1521, 8000 Aarhus C